A role for neuronal K(ATP) channels in metabolic control of the seizure gate.

ATP-sensitive K+ (KATP) channels are expressed in many different tissues including the brain,where they couple energy metabolism to cellular excitability.Although their classical role in insulin secretion in pancreatic β-cells is well understood, their neuronal function remains unclear.Now,an important study using knockout mice provides clear evidence that neuronal KATP channels are crucial players in counteracting seizure induction and propagation.